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United Kingdom


dairy cows in field in a row


Bluetongue is a notifiable disease of cattle and sheep caused by infection with bluetongue virus (BTV). Zulvac® 8 protects against serotype 8 (BTV-8).

The main route of transmission is via the Culicoides biting midge, infection therefore occurs when the biting midges are most active between May and October. BTV-8 can also pass from dam to offspring via the placenta.

In dairy cattle, infection can result in reduced reproductive performance and milk drop can be significant across the herd and across time.

Meat is safe to eat and animals can still move to slaughter but movement restrictions will affect trade. No movement of susceptible animals, semen, ovum or embryos is allowed out of the 150 km restriction zone placed around infected premises without a licence.

Zulvac 8 bovis is a vaccine for cattle against bluetongue virus serotype 8 (BTV-8). (There is a vaccine, Zulvac 8 Ovis,  specifically for sheep).  The vaccine is a ready to use suspension, containing inactivated virus with adjuvants.



Zulvac 8 Bovis (cattle)

Zulvac 8 Ovis (sheep)


Inactivated strain BTV-8/BEL2006/02
(titre ≥107.3 TCID50*/2mL dose)

Inactivated strain BTV-8/BEL2006/02
(titre ≥106.5 TCID50*/2mL dose)


Aluminium hydroxide and Saponin

Aluminium hydroxide and Saponin

Dose rate and route

2mL/animal given IM

2mL/animal given SC

Primary vaccination course

2 doses 3 weeks apart from 3 months of age

2 doses 3 weeks apart from 6 weeks of age

Onset of immunity

25 days

25 days

Duration of immunity

1 year

1 year

Use in pregnant animals

Can be used during pregnancy

Can be used during pregnancy

Vial Size

 20mL (10 doses) 100mL (50 dose)

100mL (50 dose)

(*measured before inactivation)


Benefits of Vaccinating


• Protect against the potential production losses and welfare concerns associated with BTV-8 infection

- Infertility, abortion and birth defects

- Reduced milk production

- Chronic effects such as lameness and weight loss

• Minimise disruption to movement and trade within the restriction zone should there be a disease incursion into the UK.


Illustration of the relationship of disease control zones


Vaccination plays an essential role in the control strategy for BTV-8, reducing the impact from both disease and trade restrictions should disease enter the UK.





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