How does Simparica perform on fleas?

Action against the most prevalent species

Simparica is effective against both Ctenocephalides felis and Ctenocephalides canis flea infestations in dogs¹.

Simparica was shown to have 100% efficacy for 35 days against the laboratory flea strain KS1.³ This strain has demonstrated reduced susceptibility to insecticides such as fipronil, imidacloprid and permethrin.³

Persistent killing activity

Simparica provides persistent flea killing activity for at least 35 days¹, acting beyond the monthly treatment period, helping to minimise the potential risk of protection gaps.

Immediate sustained killing activity

Simparica has been shown to start killing fleas within 3 hours⁴ and kills 95% of fleas within 8 hours for 28 days after product administration.¹ Reducing flea feeding time is key in controlling the clinical signs of FAD.

Simparica kills fleas with
immediate and persistent
effect for at least 35 days.

Percent Reduction in Arithmetic Mean of Live C.felis Counts in Simparica-treated Dogs vs. Placebo⁴

% reduction of live C.felis counts

Prevents viable egg contamination

The immediate and persistent flea killing activity of Simparica results in preventing environmental flea egg contamination for at least 5 weeks¹.

Simparica efficacy against flea egg laying⁴

% reduction in C.felis egg counts

Day of count

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References:

1. Simparica SPC. 3. Six, R.H., Geurden, T., Packianathan, R., Colgan, S., Everett, W.R., Grace, S., Hodge, A., Mahabir, S.P., Myers, M.R., Slootmans, N., Davis, K. (2016) ‘Evaluation of the effectiveness of a novel oral formulation of sarolaner (Simparica™) for the treatment and control of fleas on dogs’ Vet. Parasitol. 222 pp.18-22 4. Six, R.H., Becskei, C., Carter, L., Gale, B., Young, D.R., Mahabir, S.P., Chapin, S. and Myers, M.R. (2016) ‘Evaluation on the speed of kill, effects on reproduction, and effectiveness in a simulated infested-home environment of sarolaner (Simparica™) against fleas on dogs’ Vet. Parasitol. 222 pp. 23 -27.

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